My favorite video game is The Last of Us.
You may argue that the game itself isn't completely unique because there are hundreds of stories revolving around a post-apocalyptic world caused by an outbreak of infection, but the game focuses more on the characters than the infection itself, unlike most movies/stories that revolve around this kind of plot.
The gameplay was a solid 10/10 because of its unique mechanics (namely the real-time crafting system) and minimal user interface. I've only played the remastered edition of it, so the visuals were pretty nice, too. Along with the visuals, mechanics, and user-interface is the sound and it was also great!
As far as a video game series is concerned, my favorite series is Kingdom Hearts.